My name is Professor Denis Vivien I will talk about Imaging Neuroinflammation: From Experimental Tools to Stratification of Patient Cohorts. It's session ID SS16 It will be Thursday afternoon room room 2, at 3 pm. So as you know endothelial activation is a hallmark of cardiovascular diseases acting either as a cause or consequence of organ injury. So to date with extractable method to measure endothelial activation in vivo. However, a method which could allow us to unmask endothelial activation and thus inflammation is the context of neurological disorders, especially stroke, would help us to improve the diagnosis, prognosis and treatment of patients. So in my talk during this meeting, I would share with you the more recent data we got in this field of research in my group. Indeed, these last few years my research groups developed magnetic resonance imaging, MRI method allowing noninvasive endothelial activation mapping in the vasculature of the main organs affected during cardiovascular disease. In clinical relevant context in mice we provide evidence that this method allow detecting endothelial activation before any clinical manifestation of organ failure in the brain, kidney and heart with an exceptional sensitivity. We have now developed a new series of biodegradable particles to reveal inflammation in vivo with a good chance of transfer to human. Not only using magnetic resonance imaging MRI, but also a new modality named Magnetic Particular Imaging, MPI. With a large potential of using human to improve the stratification of patients cohorts previous treatments. I am happy to share this data at ESOC 2023. This meeting being a unique opportunity to discuss our results with people covering basic research, taking care models and the clinical application in the field of stroke.
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