Extra-Corporeal Systems in Acute Liver Failure: Quickfire videos from the ILTS Acute Liver Failure SIG

Speakers: Fuat Saner, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Florent Artru, Clinical Research Fellow - King's College Hospital, London, UK

Florent Artru: Hello, I'm Florent Artru from King's College Hospital London. On behalf of the ILTS Acute Liver Failure Special Interest Group Steering Committee, it's my pleasure to introduce this short video focusing on an emerging field in the management of acute liver failure, which is the use of extracorporeal systems. According to a large international survey launched last year, we have observed a wide heterogeneity of use of these devices worldwide ranging from 20% in Latin America to almost 90 to 100% in Australia and New Zealand. And this, despite emerging evidences regarding the potential benefit of ECLS in the field of acute liver failure, three experts from our group have summarized their opinion for and against the use of the ECLS. We hope that this video will encourage you to better explore the field and eventually participate in future research projects eventually participate in future research projects. Do not hesitate to interact on social media with this video and also with our group.

Fuat Saner: We just listened to experts in the field of acute liver failure from two different parts of the world. While Ram from the United States favors continuous renal replacement treatment in acute failure to correct acidosis and hyperammonia. He also recommend the use of high-volume plasmapheresis particularly for patients who were hemodymamic unstable. Akila from India highlighted that results from studies which were done in Europe or United States cannot easily be transferred to other countries. The studies of MARS® for acute liver failure and high-volume plasmapheresis were mainly done in France or in a study in Europe. The majority of patients with ALF suffered here from from acetaminophen intoxication while the main diagnosis in India for acute liver failure are viral hepatitis.